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KMID : 0358320090500070629
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Korean Journal of Urology
2009 Volume.50 No. 7 p.629 ~ p.634
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Urologic Applications of Cryo-Immunology
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Abhinav Sidana
Ronald Rodriguez
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Abstract
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Purpose: Cryoablation is gaining acceptance as a primary treatment of localized metastatic urologic malignancies as well as a salvage therapy. Anecdotal clinical reports suggest that cryoablation can induce a systemic antitumor immune response, which has been confirmed in animal models also. Materials and
Methods: A review of the relevant literature was performed to suggest urologic applications of cryo-immunology.
Results: This article reviews the existing evidence regarding cryo-immunology and discusses the mechanisms for generation of an anti-tumor immune response.
Conclusions: Our findings suggest combining cryoablation with other immunotherapeutic approaches to devise a cryo-immunotherapeutic strategy with potential to impact the progression of metastatic disease.
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KEYWORD
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Cryosurgery, Prostatic neoplasms, Kidney neoplasms, Immunotherapy
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